Eded to determine what role, if any, it may play in the development of chd. Another gene close to this snp is mtap, which encodes a protein that recycles certain cellular waste products into the amino acid methionine. Methionine is also produced when cells break down excess homocysteine (a molecule that has been shown to be a risk factor for atherosclerosis and heart attack). It is possible that a change in mtap function--perhaps caused by a genetic variant--could disrupt the methionine balance in cells, in turn affecting homocysteine levels and affecting risk for chd. Multiple studies have shown this snp to be associated with chd in populations of european ancestry. This association has also been replicated in east asian (chinese) and south asian populations. The association has been studied in an african american population, however more studies are needed to confirm the association in populations of african descent. Researchers have also reported that diet may influence the association between snps at the 9p21 locus and chd. A combined ethnicity study found that individuals who had two copies of the risk version of snps in this region and regularly consumed raw vegetables and fruit were not at higher risk for heart attack compared to individuals who had two copies of the protective version of snps in this region and ate a similar diet. buy cialis Individuals who had two copies of the risk version of snps in this region and did not regularly consume raw vegetables and fruit, however, were at higher risk for heart attack. (read more about this finding on our blog. levitra cialis viagra ) citations broadbent hm et al. (2008). “susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked snps in the anril locus on chromosome 9p. ” hum. Mol. Genet. 17(6):806-14. cialis canada Preuss m et al. (2010). “design of the coronary artery disease genome-wide replication and meta-analysis (cardiogram) study: a genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. why are there bathtubs in the viagra commercials ” circ cardiovasc genet 3(5):475-83. cialis 20 mg Clarke r et al. (2009). viagra use pilots “genetic variants associated with lp(a) lipoprotein level and coronary disease. ” n. Engl. J. Med. 361(26):2518-28. Helgadottir a et al. (2007). “a common variant on chromosome 9p21 affects the risk of myocardial infarction. cheap cialis ” science 316(5830):1491-3. Horne bd et al. (2008). why are there bathtubs in the viagra commercials “association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease. ” circ cardiovasc genet 1(2):85-92. Coronary artery disease consortium et al. can i use viagra with high blood pressure (2009). “large scale association analysis of novel genetic loci for coronary artery disease. taking cialis ” arterioscler. Thromb. Vasc. Biol. 29(5):774-80. Samani nj et al. (2007). “genomewide association an. VOLunter Hosting Services


 

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